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KMID : 0043320090320070975
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Archives of Pharmacal Research
2009 Volume.32 No. 7 p.975 ~ p.982
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Novel Facile Synthesis of Imidazo[1,2-b]-[1,2,4,5]tetrazines with Potential Antimicrobial Activity
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Shawali Ahmad Sami
Tawfik Nagla M.
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Abstract
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Starting from 1-amino-2-methylthio-4-phenylimidazole 2, a series of the title compounds have been synthesized via its reactions with various hydrazonoyl halides 3. The mechanism of the reactions studied is discussed. The structure of the compounds prepared were elucidated on the basis of their elemental analyses, spectral data and alternate synthesis. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.
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KEYWORD
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Hydrazonoyl halides, Nitrilimines, Heterocycles
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